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Abstract

DRUG USE EVALUATION OF INTRAVENOUS AMINOGLYCOSIDE: A PROSPECTIVE, OBSERVATIONAL STUDY

Ansh M. Arora*, Astha H. Patel, Niruj J. Patel, Harsh G. Patel1 and Mustakim M. Mansuri

ABSTRACT

Background: Antibiotic should be used appropriately, safely and only when needed. Irrational use of antibiotics is one of the major causes which leads to drug resistance in India. Drug Use Evaluation (DUE) study was designed to evaluate the use of narrow therapeutic drug class-aminoglycoside and its harmful effects thereafter. Material and Method: A prospective observational study was conducted for a period of 6 months in patients who received intravenous aminoglycoside from hospitals located at Ahmedabad. A data collection form was prepared as per DUE study requirement. Total 109 subjects were enrolled based on eligibility criteria with their prior consent. Demographic, therapeutic details and other data relevant to the study was collected for a period of 5 days. Collected data was kept confidential and analyzed statistically. Result and Discussion: In Total of 109 patients, 66 and 43 patients received amikacin and gentamicin respectively. Average daily dose of amikacin was 918.18mg and gentamicin was 156.27mg. In only 48.62% patients dose administration of aminoglycoside was as per ideal body weight. Microbial culture is important and was not paid any attention by the clinicians. Average duration of therapy for aminoglycoside was 3.16 days. For 21 different indication for which aminoglycoside was prescribed out of which 3 indication were found to be surprising. Comparable reduction in renal functioning was observed but it was not significant. Drug Induced ototoxicity was found in approximately 14% of patients. Conclusion: Aminoglycoside were used appropriately for specific and exclusive indications, but drug use problem were common in terms of dose administration based on ideal body weight. Microbial culture is important and was not paid any attention by the clinicians.

Keywords: Drug Use Evaluation, Aminoglycoside, Amikacin and Gentamicin.


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