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Abstract

NON-PRESSURIZED TOPICAL SPRAY OF DICLOFENAC DIETHYLAMINE

Neelam Pawar and Hema Chaudhary*

ABSTRACT

The objective of research work was an attempt to develop non-pressurized topical spray formulation to improve diclofenac diethylamine permeation through lipoidal membrane obstruction. A prototype formulation and thirty formulations were prepared (using different concentration of permeation enhancer, cooling, buffering, film forming agent, plasticizer and lecithin), their characterization & optimization was done (FTIR spectroscopy, drug release, skin-irritation, kinetics study performed by construct the plot of zero order/first order/Higuchi/Korsmeyer Peppa’s). A screw neck HDPE bottle procured with metered spray (200mcl) pump and actuator was selected as a dispensing system. The result demonstrated drug release of optimized formulation (F30) was found to be 93.3%±3.1μgcm-2 and its in vitro study revealed significant plus immediate topical drug permeation. According to n > value of F30 showed super case (II) transport, erosion release mechanism, moreover no skin-irritation score.

Keywords: DDEA, Non-pressurized topical spray, Metering chamber, Drug release, Kinetics, Stability.


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