Abstract

FORMULATION AND EVALUATION OF ORALLY DISINTEGRATING TABLETS OF ONDANSETRON HYDROCHLORIDE

M. Rajesh*, R. Sujin and R. Venkatesh Babu

ABSTRACT

The present investigation was aimed to prevent inherent drawbacks associated with conventional tablets of Ondansetron hydrochloride by preparing orally disintegrating tablets of Ondansetron hydrochloride which is a competitive serotonin 5-HT3 receptor antagonist. A total of seven formulations (F-I to F-VII) were prepared by direct compression method using crospovidone, sodium starch glycolate and croscarmellose sodium as superdisintegrants. Mannitol, sorbitol and microcrystalline cellulose (112) were used as diluent. All the formulations were evaluated for precompression parameters such as angle of repose, bulk density, tapped density, compressibility index and Hausner’s ratio. The prepared tablets were also evaluated for thickness, hardness, weight variation, friability, disintegration time, in vitro dispersion, fineness of dispersion, wetting time and water absorption ratio, drug content and in vitro drug release study. The results of disintegration time indicated that the tablets dispersed rapidly within 30 seconds. Dissolution study revealed faster release of Ondansetron hydrochloride (99.85%) at the end of 10 minutes. The study concluded that formulation F-VII prepared using crospovidone as superdisintegrant along with mannitol and microcrystalline cellulose as diluent was found to be better one compared to other formulations and satisfied the criteria for orally disintegrating tablets.

Keywords: Croscarmellose sodium, Crospovidone, Mannitol, Microcrystalline cellulose, Ondansetron hydrochloride, Orally disintegrating tablets.