Abstract

ONE POT GREEN SYNTHESIS OF 2-ARYL/HETERYLBENZIMIDAZOLE AS ANTI-INFLAMMATORY AGENTS

Anna Pratima Nikalje*, Mangesh Ghodke

ABSTRACT

Benzimidazole derivatives constitute an interesting class of organic compounds with diverse pharmacological activities. In view of the observations and in continuation of previous synthetic programme on the synthesis of chalcones and their derivatives, present study report the synthesis of some new benzimidazole derivatives which have been found to possess an interesting profile of anti-inflammatory activity. The present study reports an eco-friendly, one pot, microwave-assisted expeditious synthesis of 2-aryl/heteryl-substituted benzimidazole derivatives and their anti-inflammatory activity. The one pot synthesis was carried out under microwave irradiation, by condensing phenylene diamine with aryl and/or heteryl aldehydes in solvent-free conditions using zirconium oxy chloride as catalyst in borosil beaker and irradiated in synthetic microwave oven at 700W for 3-6 min. The reaction was carried out at 700C- 850C.The products were obtained in good yields and in shorter reaction times. The synthesized compounds were evaluated for in-vivo antiinflammatory activity on Wistar albino rats in carrageenan induced rat paw edema model. After 1hr compound no. 3e, after 2hr compound no. 3b, 3d and after 3hr compound no. 3d, 3e and 3h have exhibited more percentage of inhibition of anti-inflammatory activity.

Keywords: Green synthesis, eco friendly, benzimidazole, carrageenan, anti-inflammatory activity, indomethacin.