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Kalpana Agarwal and Dr. P. J. Prasuna Sundari*


Novel drug delivery System adopts various strategies to achieve controlled and targeted drug delivery. Guggulosomes are the vesicular drug delivery systems wherin the guggul lipids when triturated with the solution of the drug form drug entrapped vesicles. Guggulosomes can be utilized for therapeutic and cosmetic purpose for the delivery of the active. Guggul lipid is the standardized extract of the oleo-gum-resin of Commiphora mukul, family - Burseraceae. Scientific investigations of guggul lipid indicated it to possess anti-inflammatory, hypolipidemic, anti-obesity and anti-cancer; anti- wrinkle &anti-acne activities. Guggulosomes act synergisitically when formulated for treatment of the above conditions. The aim of the present study is to formulate and evaluate guggulosomes of diclofenac sodium and piroxicam with an objective to reduce the dose required to elicit therapeutic effect. Guggulosomes are prepared using sonication method and trituration method. In the present study guggulosome are prepared by trituration method using different drug lipid ratios. All the formulated guggulosomes were evaluated for morphology, SEM, Zeta potential, entrapment efficiency and in-vitro drug release. Evaluation data indicated diclofenac sodium guggulosome formulation F4 to be best with entrapment efficiency & % cummulative drug release of 92.5±0.361 & 90.5±5.2 respectively. F8 formulation of piroxicam guggulosome was selected as it has shown highest entrapment efficiency and % drug release of 95.54±0.251 & 95±5.4 respectively. Therefore F4 & F8 were selected for formulation as topical gels. The gels were formulated using carbapol 943 & HPMC E5 by dispersion method. All the gels were evaluated for visual apperance, pH, viscosity, spreadiability & invitro drug diffusion studies. G1 (diclofenac guggulosomal gel) demonstrated highest drug content & % drug release of 99.87 & 82±4.4 in 8 hours respectively. G5 formulation of topical piroxicam guggulosomal gel demonstrated highest drug content and % drug release of 99.77 & 86.52±2.6 in 8 hours respectively. The selected guggulosomal formulations G1 & G5 were compared with the marketed diclofenac sodium gel (Voltaren gel) & piroxicam gel (Felden gel). The results obtained show that the formulated gels have sustained drug release. However further animal studies are required to demonstrate the cumulative anti inflammatory action of the lipid.

Keywords: Guggulosomes, phospholipids, guggul lipids, anti-i

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