Photo Gallery

Login

Search

News & Updation

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS DECEMBER ISSUE PUBLISHED
  • DECEMBER 2017 Issue has been successfully launched on 1 December 2017

  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.041 to 6.647 due to high quality Publication at International Level

  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  

Abstract

FORMULATION AND EVALUATION OF METOPROLOL SUCCINATE SUSTAINED RELEASE TABLETS

V. Sai Raghava, Dr. C. Aparna* and Dr. M. Bhagavan Raju

ABSTRACT

A sustained effect of Metoprolol Succinate is required for the treatment of some chronic conditions like rheumatoid arthritis, osteoarthritis and chronic pain. Sustained release matrix tablets of Metoprolol Succinate were formulated using polymers (ethyl cellulose, Eudragit-RL100, PVP) and hydrophilic gums (guar gum, xanthan gum) in various concentrations. Hydroxy propyl methyl cellulose (HPMC), sodium carboxy methyl cellulose (Na.CMC), micro crystalline cellulose and lactose were used as fillers. Nineteen different formulations of matrix tablets of Metoprolol Succinate were produced by wet granulation and direct compression methods. The flow properties of the granules and the physical properties of the compressed tablets namely, weight uniformity, crushing strength, drug content, friability and tablet thickness were evaluated. In – vitro release studies of the drug was performed in 0.1 N HCl for 2 hrs and phosphate buffer pH 6.8 for 10 hours. The best selected formulation F14 (containing 35% of Eudragit-RL100) sustained the drug release for 12 hrs. All the physical characteristics of the formulated tablets were within acceptable limits. The best selected formulation F14 has exhibited anomalous Non-Fickian diffusion (i.e., n<1). This was observed due to the effect of swelling/erosion of polymer (Eudragit RL-100).

Keywords: Sustained release tablets, Metoprolol Succinate, Hydrophilic gums & hydrophobic polymers.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More