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Abstract

DEVELOPMENT AND VALIDATION OF NEW SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR IN BULK AND PHARMACEUTICAL DOSAGE FORM AND ITS COMPARISON WITH REPORTED METHODS

Ramya B., Vinutha K.*, Sridevi P. and M. Bhagavan Raju

ABSTRACT

Two simple, accurate, precise and sensitive spectrophotometric methods have been developed and validated for determination of Rilpivirine in bulk and pharmaceutical dosage forms. Method A and B involves the formation of a colored chloroform extractable ion pair complex of drug with bromothymol blue and Bromocresol green absorbing maximally at 425nm and 415nm. Beer’s law is obeyed in the concentration range of 4-20μg/ml for methods A and B. Molar absorptivity, Sandell’s sensitivity, Association constant, Limit of Quantification and Limit of Detection were calculated. The proposed methods were successfully applied for the determination of Rilpivirine in pharmaceutical formulation.

Keywords: Rilpivirine, Spectrophotometry, Bromothymol blue, Bromocresol green, ion-pair complex, Validation.


[Full Text Article]

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