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Abstract

FORMULATION AND EVALUATION OF SUSTAINED RELEASE TABLETS OF PROPRANOLOL HYDROCHLORIDE

Gore Meghana*, Gurav Yogesh and Gharge Varsha

ABSTRACT

The main aim of proposed work was to develop propranolol hydrochloride matrix tablets, sustained release dosage form, for the treatment of hypertension. Sustained release formulation is the drug delivery system that designed to achieve a prolonged therapeutic effect by continuously releasing medication over an extended period of time after administration of single dose. The matrix tablets were prepared by direct compression method using hydroxypropymethylcelluose (HPMC K4M), Avicel pH 102, magnesium stearate and talc. In the formulation HPMC K4M and magnesium stearate used in varying ratios. Tablets blends were evaluated for loose bilk density, tapped density, compressibility index and angle of repose shows satisfactory results. The compressed tablets were then evaluated for various physical tests like diameter, thickness, uniformity of weight, hardness, friability and drug content. The results of all these tests were found to be satisfactory. The in vitro dissolution study was carried out for 12 hours using paddle method in phosphate buffer (pH6.8) as dissolution media. Formulation F6 shows – of drug release at the end of 12 hours.

Keywords: HPMC K4M, Propranolol hydrochloride, matrix tablets.


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