WJPPS Citation

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • New Impact Factor
  • WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

  • WJPPS: MARCH ISSUE PUBLISHED
  • March Issue has been successfully launched on 1 March 2024.

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Scope Indexed
  • WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

Abstract

SOLUBILITY ENHANCEMENT OF POORLY SOLUBLE SAQUINAVIR BY USING SELF-EMULSIFYING DRUG DELIVERY SYSTEM

T. Hiranmai, G. Nagaraju* and V. Sirisha

ABSTRACT

A self-micro-emulsifying drug delivery system (SMEDDS) has been developed to enhance dissolution rate and oral bioavailability of saquinavir. The solubility of saquinavir was checked in different oils, surfactants and co-surfactants and ternary phase diagrams were constructed to evaluate the micro emulsion domain. The saquinavir SMEDDS was prepared using Capmul MCM (oil), Cremophor RL100 (surfactant) and labrafil (co-surfactant). The particle size was determined. Dissolution rate of saquinavir was measured by using 0.1 N HCL as diffusion media. Results of diffusion rate of saquinavir SMEDDS were compared with those of pure drug solution. Diffusion of saquinavir SMEDDS showed maximum drug release when compared to pure drug solution.

Keywords: Saquinqvir, Self-micro-emulsifying Drug Delivery System.


[Download Article]     [Download Certifiate]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More