Photo Gallery

Login

Search

News & Updation

  • WJPPS JULY ISSUE PUBLISHED
  • JULY 2018 Issue has been successfully launched on 1 July 2018

  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  

Abstract

SOLUBILITY ENHANCEMENT OF POORLY SOLUBLE SAQUINAVIR BY USING SELF-EMULSIFYING DRUG DELIVERY SYSTEM

T. Hiranmai, G. Nagaraju* and V. Sirisha

ABSTRACT

A self-micro-emulsifying drug delivery system (SMEDDS) has been developed to enhance dissolution rate and oral bioavailability of saquinavir. The solubility of saquinavir was checked in different oils, surfactants and co-surfactants and ternary phase diagrams were constructed to evaluate the micro emulsion domain. The saquinavir SMEDDS was prepared using Capmul MCM (oil), Cremophor RL100 (surfactant) and labrafil (co-surfactant). The particle size was determined. Dissolution rate of saquinavir was measured by using 0.1 N HCL as diffusion media. Results of diffusion rate of saquinavir SMEDDS were compared with those of pure drug solution. Diffusion of saquinavir SMEDDS showed maximum drug release when compared to pure drug solution.

Keywords: Saquinqvir, Self-micro-emulsifying Drug Delivery System.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More