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Abstract

FORMULATION OF METOPROLOL SUCCINATE MICROSPHERES EMPLOYING NOVEL BIODEGRADABLA POLYMER “O-PALMITOYL PULLULAN” AS A POTENTIAL CARRIER IN THE EVALUATION AND STABILITY

Ch. Taraka Ramarao* and M. SKNSC. Kishore

ABSTRACT

In the present investigation was attempts have been made to prepare metoprolol Succinate microspheres employing O-Palmitoyl pullulan (OPP) microspheres bearing ionotropic gelation method for sustained drug delivery. OPP was then synthesised from pullulan by chemically modifying with palmitoyl chloride and microspheres of metoprolol Succinate employing both OPP and sodium alginate were prepared. These prepared microspheres though gave a slow release, it was observed that more than 90% of drug released by 10-11 hrs itself or not uniformly spread throughout the expected 12 hrs. Formulation (F7) drug release was more controlled and the drug release was controlled up to 12 hours. Formulation (F7) followed zero order release kinetics and they showed Non-Fickian type of diffusion. If pharmaceutical preparations or new formulations are stored under normal conditions, their instabilities are detectable only after long storage periods. Such a method is time consuming and uneconomical. In an attempt to reduce the time required to obtain information about instabilities, various stress tests are undertaken. The most common stress conditions used are temperature, humidity and light. The stability studies conducted revealed that there was no change in the drug release profile after the products were stored at 37±20C and 75 + 5% RH and there was no significant drug loss after storage. Due to its biodegradable and non toxic nature OPP can be further used in different pharmaceutical formulations.

Keywords: O-Palmitoyl pullulan (OPP), Microsphere, Entrapment efficiency, Swelling index, SEM.


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