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Abstract

A REVIEW ON COMPOSITION AND PREPARATION OF BIORELEVANT MEDIA

Gumpula Swapna*, Ch. Malathi Suvarna, Merugu Manasa, N. Siva Subramanian, G. Sandesh and J. Suprabath

ABSTRACT

Biorelevant Media are biologically relevant fluids which are incredibly accurate simulations of juices found in the gut at various times of day. Biorelevant media is used to reproduce the conditions in the gastrointestinal (GI) tract In-vitro, so that the behavior of drugs and dosage forms in the GI tract can be studied in the laboratory.These are used for In-vitro solubility and dissolution studies along with the study of decomposition under GI conditions along with the determination of permeability of the drug. During the development of new a product, testing it in Biorelevant Media can be of more help to predict its behaviour during its entry and movement along the gut than with the traditional buffers. Biorelevant Media can help to establish the product solubility, time of solubility in gut, location of drug release in gut, effect of different substances on absorption of drug by In-vitro experiments since, the failure of a drug or active agent from its formulation or its dissolution in the gut fluids at the right time, will lead to decreased or no absorption by the body.This review article particularly discloses novel compositions and method for preparing reproducible and consistent fasted state and fed state bio relevant media such as FaSSIF, FaSSGF, FaSSIF-V2, FaSSIF-midgut, Dog FaSSIF, Dog FaSSGF, FaSSCoF, FeSSIF, FeSSIF-V2, FeSSIF-midgut, FeSSCoF defined by selected bio relevant components and physicochemical parameters that simulate fasted state fluids in the stomach and intestine.

Keywords: Biorelevant media, Gut, FaSSIF, FeSSIF, FaSSGF, FeSSGF, FeSSCoF, FaSSCoF.


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