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Abstract

EFFECT OF FLAXSEEDS ON ISOPROTERENOL INDUCED CARDIOTOXICITY IN RATS

Raghad Fayez Alfayez*, Soheir Ahmed Al-Masri and Nawal Abdullah Albadr

ABSTRACT

The present study was performed to explore the potential effects of flaxseed against isoproterenol induced cardiotoxicity in rats. Forty rats classified into control negative group and isoproterenol induced cardiac toxicity (85 mg/kg body weight) four rat groups that reclassified into untreated control positive and flaxseed powder, oil and extract treated rat groups. The study was assigned for 60 day. Administration of flaxseed either in form of powder, oil and extract improve of nutritional indicator (weight gain, food efficiency ratio and protein efficiency ratio) reducing hyperlipidemia (lower serum total cholesterol, LDLc, VLDLc and elevate HDLc), decline in atherogeneses (total cholesterol/ HDLc) normalize values of liver parameters (cholesterol, T. lipids, TG, ALT, AST, ALP and LDH) and antioxidant markers (SOD and catalase along with significant lower in the level of malondialdehyde, cardiac XO, LDH and NO). It can be concluded that the administration flaxseed powder, oil or extract can lower the side effects of isoproterenol induced cardiotoxicity in rats and reducing the risk factors for cardiovascular disease such as hyperlipidemia, leakage of cardiac markers and nutritional indicators.

Keywords: Isoproterenol- flaxseeds- hyperlipidemia- cardiac marker-rats.


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