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Abstract

SIMPLE AND RAPID DETERMINATION OF ROSUVASTATIN IN HUMAN PLASMA BY LC-MS/MS

Kumaraswamy Gandla*, Lalitha Repudi, Surya Prakasarao Kovvasu and R. Nageswara Raoc

ABSTRACT

An LC-MS/MS method was developed and validated for the determination of rosuvastatin in human plasma. Rosuvastatin d6 was used as an internal standard (IS). The plasma samples were extracted by simple solid phase extraction method. These samples were then chromatographed on a C18 column by using a mixture of 5mM ammonium acetate (pH 3.5) and acetonitrile (20:80, v/v) as the mobile phase. The method was validated in the range of 0.51–100.9 ng/mL with r2  0.99. The intra–day and inter–day precision and accuracy results in four validation batches across five concentration levels were well within the acceptance limits.

Keywords: Rosuvastatin; Human plasma; Solid-phase extraction (SPE); LC–MS/MS.


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