Abstract

EFFECTS OF ETHANOLIC EXTRACT OF TECOMA STANS LEAF ON REPRODUCTIVE PERFORMANCE IN STREPTOZOTOCININDUCED DIABETIC RATS

C. K. Tyagi, Harshita Rajoria, Sunil Kumar Shah*, Neelesh Chaubey, Harish Pandey, H. K. Sharma and Priyanka Pandey

ABSTRACT

The present study was formulated to Effects of Ethanolic Extract of Tecoma stans leaf on reproductive performance in streptozotocininduced diabetic rats. Effects of ethanolic extract of Tecoma stans leaf extract were studied on physicochemical parameters, successive solvent extraction, and phytochemical screening and reproductive performance in streptozotocin-induced diabetic rats. After acute oral toxicity study, streptozotocin-induced diabetic albino rats are grouped into four groups, Normal control albino rats (Group I) received saline solution, Positive control albino rats (Group II) received alloxan mono hydrate, Standard group albino rats (Group II1) Received alloxan mono hydrate + glibenclamide2.5mg/kg) and Treated group (Group IV) received alloxan mono hydrate + Tecoma stans leaf ethanolic extract (200 mg/kg). The ethanolic extract group was compared with standard group and positive control group. At the end of the study (15th day) the glibenclamide (2.5 mg/kg.) and ethanolic extract of Tecoma stans leaf (200 mg/kg) showed statistically more significant in decrease blood glucose level .The ethanolic extract shows (157.5±4.4) more significant value (**p<0.01) when compared to positive control group and near to standard group. The standard group shows (124.6±3.9) and shows significant value (**p<0.01).The antidiabetic activity of ethanolic extract of Tecoma stans leaf may be due to potentiation of insulin secretion from β-cells of pancreas, i.e., pancreatotropic action.

Keywords: The Tecoma stans were collected from the garden of College of Pharmacy.