Abstract

ANIMAL MODELS OF HYPERTENSION, DIABETES AND DIABETIC HYPERTENSION: AN OVERVIEW

*GB Jadhav, RB Saudagar and CD Upasani

ABSTRACT

Hypertension is the most common cardiovascular disease and is a major public health issue in developed as well as developing countries. Changes in human behavior and lifestyle over the last century have resulted in dramatic increase in the incidence of diabetes worldwide Hypertension is twice as prevalent in people with diabetes as in the general population. Both hypertension and diabetes are independent risk factors for micro vascular and macrovascular disease. There is need to search new techniques for evaluation of efficacy of new drugs on diabetic hypertension. The objective of the present review was to study various animal models of experimental induced diabetic hypertension in animals. Though there are some research papers and reviews available on the animal models of diabetic hypertension, the aim of this review, however, is highlight on overview on the currently available animal models of diabetic hypertension with respect to their origin/source, characteristic, advantages, and disadvantages in in human. Further, it especially deals with the appropriate selection and usefulness of different animal models in testing various classes of new chemical entities (NCEs) and other therapeutic modalities for the treatment of diabetic hypertension.

Keywords: Animal models, Diabetes, hypertension, DOCA, STZ.