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  • WJPPS NOVEMBER ISSUE PUBLISHED
  • NOVEMBER 2017 Issue has been successfully launched on 1 November 2017

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  • WJPPS Rank with Index Copernicus Value 52.51 due to high reputation at International Level

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  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.041 to 6.647 due to high quality Publication at International Level

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Abstract

FORMULATION AND EVALUATION OF ORAL DISSOLVING FILMS OF FEXOFENADINE

T. Praveen Kumar*, V. Sindhu and S. Bhavya

ABSTRACT

The main objective of the present work was to develop the oral dissolving films of Fexofenadine. Total 12 formulations were prepared by using different viscosity grades of HPMC such as E3, E6 and E15 by solvent casting method. The films were characterized for various physicochemical parameters such as weight variation, thickness, folding endurance, % drug content, In vitro disintegration time and In vitro dissolution time. The results of quality control tests were found to be within the acceptable limits. The thickness of the films was found to be in the range of 0.12 mm to 0.24 mm. The folding endurance was found to be more than 300. The In vitro disintegration time of the films was found to be between 18-62 sec. The invitro dissolution time of the films was found to be between 15-30mins in most of the formulations. FTIR and DSC study revealed that there is no drug – polymer interactions. SEM study showed that films were clear, transparent and had a smooth surface texture. It was concluded that fexofenadine oral dissolving films can be prepared by using different viscosity grades HPMC with good commercial success.

Keywords: Fexofenadine, HPMC, oral dissolving film, solvent casting technique.


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