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Abstract

COMPARATIVE IN-VITRO CHARACTERIZATION OF DIFFERENT COMMERCIALLY AVAILABLE BRANDS OF PANTOPRAZOLE SODIUM TABLETS

Susanta Paul*, Anannya Bose, Indrani Konar, Dr. Pradip Kumar Kara, Tathagata Roy and Payel Mukherjee

ABSTRACT

The present study is concerned to characterize and compare the various physico-chemical properties like thickness, hardness, weight variation, friability and disintegration time, in-vitro dissolution profile of the pantoprazole sodium for different brands of tablets containing (40mg) prepared by various pharmaceutical industries under different trade names. All the brands passed all the official tests as prescribed by the Pharmacopoeia. All the brands were within the limit when tested for Thickness, Weight variation, Hardness, Friability and Disintegration. The four brands of pantoprazole sodium 40 mg (B1, B2, B3, B4) was found to have ideal disintegration time as well as dissolution time. The U.V. Spectrophotometric method for the assay of Pantoprazole tablets used in this study is simple, inexpensive, reproducible and easy to use and could be used in routine monitoring of the quality of the pantoprazole sodium tablets, especially in the absence of high technology equipment.

Keywords: Pantoprazole Sodium, Enteric coated tablets, Pharmacopoeia, Comparative In-Vitro evaluation.


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