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  • WJPPS NOVEMBER ISSUE PUBLISHED
  • NOVEMBER 2017 Issue has been successfully launched on 1 November 2017

  • ICV
  • WJPPS Rank with Index Copernicus Value 52.51 due to high reputation at International Level

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  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.041 to 6.647 due to high quality Publication at International Level

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Abstract

BIOANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF RIBAVIRIN IN RAT PLASMA BY RP-HPLC METHOD

Dr. Sonali Paresh Mahaparale*, Rasika Pramod Karandikar and Kundan B. Bhalerao

ABSTRACT

A simple, rapid, selective, sensitive, accurate and precise High Performance Liquid Chromatography (HPLC) with UV detection method has been developed and validated for determination of Ribavirin in rat plasma. C18 (250x4.6mm) column was used with the mobile phase containing a mixture of Acetonitrile: Water (60:40v/v). The flow rate was 1ml/min and drug was monitored at 218 nm. Plasma samples were processed using acetonitrile as precipitating agent to extract drug. The linearity for Tolperisone hydrochloride was found to be 0.5 to 12 μg/ml with regression coefficient (r2) 0.9990. The recovery was found to be 88.09%.

Keywords: Ribavirin, Reverse phases HPLC, Accuracy, Precision, Robustness, LOD, LOQ, and Specificity.


[Full Text Article]

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