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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript

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WJPPS Invited to submit your valuable manuscripts for Coming Issue.

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New Impact Factor

WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

Scope Indexed

WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

WJPPS: APRIL ISSUE PUBLISHED

April Issue has been successfully launched on 1 April 2024.

Abstract

BIOANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF RIBAVIRIN IN RAT PLASMA BY RP-HPLC METHOD

Dr. Sonali Paresh Mahaparale*, Rasika Pramod Karandikar and Kundan B. Bhalerao

ABSTRACT

A simple, rapid, selective, sensitive, accurate and precise High Performance Liquid Chromatography (HPLC) with UV detection method has been developed and validated for determination of Ribavirin in rat plasma. C18 (250x4.6mm) column was used with the mobile phase containing a mixture of Acetonitrile: Water (60:40v/v). The flow rate was 1ml/min and drug was monitored at 218 nm. Plasma samples were processed using acetonitrile as precipitating agent to extract drug. The linearity for Tolperisone hydrochloride was found to be 0.5 to 12 μg/ml with regression coefficient (r2) 0.9990. The recovery was found to be 88.09%.

Keywords: Ribavirin, Reverse phases HPLC, Accuracy, Precision, Robustness, LOD, LOQ, and Specificity.

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