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  • WJPPS NOVEMBER ISSUE PUBLISHED
  • NOVEMBER 2017 Issue has been successfully launched on 1 November 2017

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Abstract

FORMULATION DEVELOPMENT AND EVALAUATION OF IMMEDIATE RELEASE TABLETS OF TELMISARTAN

Ravulakollu Balaji*, Fathima Asra and Manohar Babu S.

ABSTRACT

In the present research work, Telmisartan Immediate release tablets were prepared by using Super disintegrants like crosscarmellose sodium, crospovidone and sodium starch glycolate in different concentrations by direct compression method. Telmisartan Immediate release tablets prepared were evaluated for pre-compression and post-compression parameters. The pre-compression parameters evaluated are bulk density, true density, angle of repose and percentage porosity where the angle of repose of all the formulations is below 30º indicating free flowing. Post-compression parameters like hardness, weight variation, percent friability, In vitro dispersion, drug content uniformity and In-vitro drug release studies were carried out for all the formulations. Hardness of the tablet of every batch was in the range of 2.8 to 4.0 kg/cm2.Friability of all the tablets was less than 1%. Weight variation test results of every batch showed that the weight of each tablet of the batch tested was within the range ±7.5%. All the tablets formulated using crosscarmellose sodium, crospovidone and sodium starch glycolate disintegrated within 3 minutes fulfilling the official limits of the Immediate release tablets. Drug content uniformity study results showed that the drug Telmisartan was uniformly distributed throughout the formulation of every batch. All the formulations given the result within the official limits. Formulation F2 in which Crospovidone (60mg) used, shows less disintegration time i.e. 35 seconds and highest Dissolution rate 99.9% release in 35 minutes which is considered as Best Formulation amongall.

Keywords: Telmisartan, Immediate release tablets, Direct compression method, pre-compression and post-compression parameters.


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