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*Chandrika Y. and Dr. Sathish C. S.


Objective: The aim of the present work is to design and evaluate the buccal patches of NSAID’s for gingivitis using different mucoadhesive polymers such as hpmc 5cps, carbopol 934p, eudragit rl 100 in various combination. Method: The buccal patches were prepared by solvent casting method. The formulation of buccal patch, dose is released immediately due to presence of polymer in different concentration. All the buccal formulation were subjected to pre-formulation and physical evaluation studies, jn-vitro drug release and ex-vivo permeation studies. In-vitro drug release from the formulation was studied using buffer pH 6.8. Results: From in vitro studies formulation F6 and F7 were selected for mucoadhesive studies and ex vivo permeation studies using buffer Ph 6.8. After all studies formulation F7 containing hpmc 5cps and eudragit rl 100 in the ratio (400 mg: 200 mg) was selected as optimized formulation and its muccoadhesive strength and exhibited optimum drug release. FTIR results showed no evidence of interaction between the drug and polymers. Conclusion: It was concluded that the assay of the formulations revealed that the drug content was within the limits. The results indicated that delivery of aceclofenac to the local drug delivery via the buccal route improve its bioavailability and also was found to be stable during stability studies conducted for 3 months as per ICH guidelines.

Keywords: Aceclofenac; buccal patches; mucoadhesive polymers; physicochemical parameters; In vitro drug release; Mucoadhesive studies; Ex vivo permeation studies; stability studies.

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