Abstract

SERUM OSTEOCALCIN CONCENTRATION AND ITS ASSOCIATION WITH SOME CLINICAL PARAMETERS IN DIABETES MELLITUS

Thikra A. Allwsh and Liqa'a S. Abdulla*

ABSTRACT

The research included estimate the concentration of osteocalcin and some clinical parameters in control and diabetic patients (Type I and Type II). The results demonstrated that the normal mean of osteocalcin in serum was (28.07 ± 4.79 ng/mL) in control group. also, the results demonstrated a significant decrease in the concentration of osteocalcin in serum of type I and type II diabetic patients compared with control and between type I diabetic patients compared with type II. The results also showed a significant increase in the concentration of all from glucose, MDA, total lipids, total cholesterol, triglyceride, VLDL-C, LDL-C, atherogenic Index, potassium, and in trehalase activity in serum of diabetic patients(type I and II), while found a significant decrease in the concentration of all from insulin, HOMA-β, and thioredoxin, in serum of diabetic patients (type I) compared with control and diabetic patients(type II) and a significant decrease in the concentration of all from GSH, HDL- C, Antiatherogenic Index, sodium, calcium, magnesium and zinc in serum of diabetic patients (type I and II) compared with control. Also, the results showed a significant increase of insulin resistance in type II diabetic patients compared with control and type I diabetic patients, and a significant increase of adiponectin concentration between type I diabetic patient compared with type II and control. Correlation coefficients between osteocalcin and some clinical parameters of control and diabetic patients showed that osteocalcin concentration has a significant negative correlation with concentration of all from glucose, HOMA-IR, total cholesterol, triglycerides, VLDL, LDL-C, atherogenic Index, and in trehalase activity and a significant positive correlation with concentration of all from HOMA-β, thioredoxin, GSH, HDL, antitherogenic Index, sodium, calcium and zinc in control and diabetic patients(type I and II). While osteocalcin has a significant negative correlation with concentration of all from MDA, total lipids and a significant positive correlation with concentration of all from insulin, adiponectn, and magnesium in control and type II diabetic patients, whereas osteocalcin has a significant negative correlation with potassium concentration in type II diabetic patient.

Keywords: Osteocalcin, thioredoxin, Diabetes, Clinical parameters, Insulin resistance.