Photo Gallery

Login

Search

News & Updation

  • WJPPS NOVEMBER ISSUE PUBLISHED
  • NOVEMBER 2017 Issue has been successfully launched on 1 November 2017

  • ICV
  • WJPPS Rank with Index Copernicus Value 52.51 due to high reputation at International Level

  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.041 to 6.647 due to high quality Publication at International Level

  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  

Abstract

SYNTHESIS AND ANTICANCER ACTIVITY OF NOVEL 1,3-THIAZOLE DERIVATIVES

Elsherbiny H. Elsayed, Jehan A. Hasanen* and Maha El-Ashry

ABSTRACT

2,5-disubstituted and 2,4-disubstituted thiazoles (2) and (3) were obtained from the reaction of 2,3-dihydroxybenzaldehyde thiosemicarbazone with p-chlorophenacyl bromide in different conditions. Acylation and alkylation of compound (2) and (3) with acetic anhydride and methyl iodide yielded the corresponding triacetyl derivatives (4 and 7) and N-methyl derivatives (5 and 8), respectively. Condensation of compound 3 with aromatic aldehyde in the presence of piperidine gave the corresponding aryl vinyl azo derivative (10a,b). Some thiazole derivatives were evaluated for their anticancer activity against MCF-7 and Hep-G2 cell lines. Among the tested compounds highest activity against liver carcinoma cells (Hep-G2) cell lines than the breast cancer (MCF-7) cell lines. The results showed that the investigated compounds (2,3,5,8) and (10a) had a significantly greater cytotoxic effect against human hepatocellualr carcinoma cells (Hep-G2) compared to that of other compounds (4) and (6).

Keywords: p-chlorophenacyl, piperidine, hepatocellular.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More