CHEMICAL PENETRATION ENHANCERS- A REVIEW
Shelke Suvarna Jagannath*, Shinkar Dattatraya Manohar, Saudagar Ravindra Bhanudas
ABSTRACT
The transdermal route has been identified as one of the highly potential
routes of systemic drug delivery and provide the advantages of
escaping of the first-pass effect, ease of use and withdrawal (in case of
side effects), and better patient compliance.Skin as an important site of
drug application for both local and systemic effects. However, the
major limitation of this route is the difficulty of permeation of drug
through the skin. To improve the transdermal drug delivery,
penetration enhancers are used which penetrate into skin to reversibly
decrease the barrier resistance. Chemical enhancers that aid absorption
of co-administered moieties are currently believed to improve
solubility within the stratum corneum or increase lipid fluidity of the
intracellular bilayers. This review concern with the detail information
of advantages, mechanism of action of chemical penetration enhancer and different chemical
penetration enhancers used in transdermal drug delivery.
Keywords: Transdermal drug delivery, Skin, Chemical penetration enhancers.
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