SUSTAINED RELEASE MATRIX TYPE DRUG DELIVERY SYSTEM: A REVIEW
Vinay Kumar*, S K Prajapati, Girish C Soni, Mahendra Singh, Neerajkumar
Institute of Pharmacy, Bundelkhand University, Jhansi-284128. U.P. India.
ABSTRACT
In recent years scientific and technological advancements have been
made in the research and development of oral drug delivery system.
The reasons that the oral route achieved such popularitpy may be in
part attributed to its ease of administration. Presently pharmaceutical
industries are focusing on development of sustained release
formulations due to its inherent boons. Sustained release dosage forms
are designed to release a drug at a predetermined rate by maintaining
a constant drug level for a specific period of time with minimum side
effects. Hydrophilic gel-forming matrix systems are widely used in
oral controlled-release dosage forms. Hydrophilic polymer hydrates
form a viscous gel layer around the tablet surface, and drug release is
controlled in a sustained manner by diffusion through a gel layer and
the erosion of the gel. Drug solubility, however, greatly affects the
rate of diffusion and erosion. It is especially difficult to control the release rate of highly
water-soluble and insoluble drugs. Moreover, various gastrointestinal factors such as ionic
strength and mechanical destructive force also affect the drug-release rate. To solve these
problems or predict these influences, many studies have examined factors affecting drug
release. Sustained release products are designed to bring the blood level of a drug
immediately to therapeutic concentrations by means of an initial dose portion called loading
dose and then sustain this level for a certain predetermined time with the maintenance
portion. The basic goal of sustained release is provide promising way to decrease the side
effect of drug by preventing the fluctuation of the therapeutic concentration of the drug in
the body and increase patient compliance by reducing frequency of dose.
Keywords: sustained release, Oral controlled release drug delivery system, Hydrophilic Matrix system. Patient compliance.
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