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  • WJPPS MARCH ISSUE PUBLISHED
  • MARCH 2019 Issue has been successfully launched on 1 March 2019

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  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

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Abstract

EVALUATION OF HYDROETHANOLIC EXTRACT OF OPUNTIA MONACANTHA HAW CLADODES FOR ANTIPYRETIC ACTIVITY

Muhammad Kifayatullah*, Ishrat Waheed

ABSTRACT

Opuntia monacantha Haw is a small tree with fibrous roots belongs to family of Cactaceae, having great potency in treating certain common diseases like fever, urinary problem, inflammations, tumors, piles, ulcers, anemia, and bronchitis traditionally. Previously studies showed that the Opuntia monacantha Haw has good effect against diabetes, microbes and oxidative stress, however no work was carried out for in vivo antipyretic activity. The present study was made to investigate the hydroethanolic extract of Opuntia monacantha Haw cladodes for antipyretic activity, compared to that of Aspirin as a reference drug. Pyrexia was induced by s/c injection of aqueous suspension of yeast 20% w/v in normal saline at the rate of 10ml/kg body weight. The experiment was done at the doses of 200mg/kg, 400mg/kg and 800 mg/kg B/w. Rectal temperatures were recorded for 4 hrs by digital thermometer (Holden medical B.V, Netherlands). The result showed that Opuntia monacantha Haw has strong p< 0.01 antipyretic activity and this strongly support the ethanophrmacological uses of Opuntia monacantha Haw as antipyretic agent.

Keywords: Opuntia monacantha Haw, Yeast-induced pyrexia, Antipyretic, Aspirin.


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