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Abstract

SYNTHESIS AND ANTI MICROBIAL & ANTI CANCER EVALUTION OF SOME QUINOLINE DERIVATIVES

Srinivas Sangu* and Vijaya Kuchana

ABSTRACT

Quinoline derivatives are reported to have anti microbial, anti inflammatory, analgesic and anti cancer activities. The incorporated oxymethyl carbamide at 8th position of the quinoline ring was found to influence the biological activities of the molecules with this some of new quinolinyl oxymethyl azetidinones and quinolinyl oxymethyl azetidinones thiazolidinones were synthesized from 8-hydroxy quinoline through (quinolin-8yloxy) acetyl hydrazide intermediates. All the synthesized compounds were characterized by IR, H1NMR spectral data and evaluated for their anti microbial activity.

Keywords: anti microbial activity, azetidinones, thiazolidinones.


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