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  • WJPPS OCTOBER ISSUE PUBLISHED
  • OCTOBER 2017 Issue has been successfully launched on 1 October 2017

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  • WJPPS Rank with Index Copernicus Value 52.51 due to high reputation at International Level

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  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.041 to 6.647 due to high quality Publication at International Level

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    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
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Abstract

FORMULATION AND EVALUATION OF GLIMEPIRIDE LIPOSOMAL DRUG DELIVERY SYSTEM

Dr. Khaja Pasha* and Dr. Shahana Banu

ABSTRACT

The drug release from Liposomes depends on many factors including the composition of Liposomes, the type of drug encapsulated and nature of the cell. Once it is released a drug that normally crosses the membrane of a cell will enter the cell, other drugs will not enter. Glimepiride is a drug with narrow therapeutic index and short biological half-life. This study aimed at developing and optimizing liposomal formulation of Glimepiride in order to improve its bioavailability. In evaluation study the effect of the varying composition of lipids on the properties such as encapsulation efficiency, particle size and drug release were studied. Phase transition study was carried out to confirm the complete interaction of Glimepiride with bilayer structure of liposome. Moreover, the release of the drug was also modified and extended over a period of 8 h in all formulations. F1 emerged as the most satisfactory formulation in so far as its properties were concerned. Further, release of the drug from the most satisfactory formulation (F1) was evaluated through dialysis membrane to get the idea of drug release.

Keywords: Liposomes, Glimepiride, bioavailability.


[Full Text Article]

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