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  • WJPPS MARCH ISSUE PUBLISHED
  • MARCH 2019 Issue has been successfully launched on 1 March 2019

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  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

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Abstract

DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF BRIMONIDINE INTO OCULAR IMPLANTS

Júlio Fernandes de Souza*, Kamila Nunes Maia, Sílvia Ligório Fialho, Frank Pereira de Andrade, Gisele Rodrigues da Silva

ABSTRACT

A spectrophotometric method was developed and validated to perform the determination of brimonidine incorporated into chitosan implants and released from them. Brimonidine was detected at 258 nm. The analytical method was linear (R² > 0.99) over the concentration range of 0.5 to 15 μg mL-1 of brimonidine, precise (RSD < 5.0%), accurate (with average recoveries ranging of 96 to 102%) and robust. The theoretical quantitation limit was 0.015 μg mL-1. The validated method was applied to quantify the brimonidine incorporated into chitosan implants; and it demonstrated the uniform distribution of the drug in these implantable devices. Finally, the spectrophotometric method showed the controlled and prolonged in vitro release of brimonidine that was incorporated into the chitosan.

Keywords: method validation; brimonidine; in vitro drug release; brimonidine-loaded chitosan implants; spectrophotometry.


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