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Abstract

FORMULATION AND EVALUATION OF AMBROXOL HYDROCHLORIDE SUSTAINED RELEASE MICROSPHERES

Dr. Khaja Pasha* and Dr. Shahana Banu

ABSTRACT

Sustained release microspheres of Ambroxol Hcl, It used as a Recipiratory Disease Ambroxol Hcl is water soluble drug, having low oral bioavailability (33-55%) due to complete metabolism of drug available in market were having daily administration. The present study was formulate and evaluate Ambroxol Hcl microspheres to increase oral bioavailability, decrease the frequency of drug administration, and improves patient compliance. In this study, Ambroxol Hcl microspheres was prepared by Ionotropic gelation technique using Sodium alginate, HPMC and Ethylcellulose as polymers and these prepared Ambroxol Hcl microspheres evaluated were percentage yield, particle size, drug entrapment efficiency and in vitro drug release studies. These microspheres results showed that percentage yield, entrapment efficiency, particle size and drug release studies were influenced mainly by concentration of polymer, type of polymer and stirring speed also. The results of in vitro drug release studies shows that the desired release rate is achieved by optimized formulation are releasing the drug up to 11 hrs. Optimized Ambroxol Hcl microspheres showing discrete, spherical microspheres.

Keywords: Ambroxol Hcl, HPMC, Ethylcellulose, Ionotropic gelation technique.


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