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Abstract

PREVALENCE OF MULTIDRUG-RESISTANT (MDR) AMONG CLINICAL BACTERIAL ISOLATES IN EL-GHARBIA GOVERNORATE AND EFFICIENCY OF ANTIBIOTIC COMBINATIONS

Mervat Aly Abo-State*, Soheir Saad Abd El-Salam and Rania Assi

ABSTRACT

Prevalence of multidrug-resistance (MDR) bacteria represents a great problem worldwide. Survey to determine the susceptibility profile of clinical bacterial pathogenic strains to the most commonly prescribed antibiotics by physicians in Egyptian hospitals have been determined between 20/5/2013 to 15/9/2014. Out of 200 bacterial isolates, 144(72%) were Gram-negative bacilli (GNB), 54(27%) Gram-positive cocci and two (1%) were Candida spp. The most frequent pathogens were Klebsiella spp. (42%) followed Staph. aureus (16%) and E.coli (15.5%). The most resistant isolates were Pseudomonas spp. (79 %). The most efficient antibiotic was amikacin (AK) (48.5%), while most bacterial isolates were resistant to spectinomycin (SPT) (93%). The results showed that aminoglycoside antibiotics were the most efficient agents against the clinical bacterial isolates. And from the beginning to the end of the collection period, it was found that MDR bacterial isolates 186 isolates out of 200 (93%), these MDR involved 59 XDR isolates which represented 29.5%. The sensitive isolates were found to be 14 isolates (7%) from all the isolated strains. The results of MIC50 proved that amikacin (AK) having the lowest MIC against most MDR strains tested when compared with the two other antibiotics (aztreonam (ATM) and meropenem (MERO)). This results confirmed the previous results of the present study that AK was the most effective antibiotics. The percentage of growth inhibition of double, triple and four antibiotic combinations revealed that inhibition exceeded 95% for most combinations.

Keywords: Antibiotic resistance, Pathogenic bacteria, susceptibility, MDR, XDR, antibiotic combinations.


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