WJPPS Citation

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • New Impact Factor
  • WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

  • WJPPS: MARCH ISSUE PUBLISHED
  • March Issue has been successfully launched on 1 March 2024.

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Scope Indexed
  • WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

Abstract

PREVALENCE OF MULTIDRUG-RESISTANT (MDR) AMONG CLINICAL BACTERIAL ISOLATES IN EL-GHARBIA GOVERNORATE AND EFFICIENCY OF ANTIBIOTIC COMBINATIONS

Mervat Aly Abo-State*, Soheir Saad Abd El-Salam and Rania Assi

ABSTRACT

Prevalence of multidrug-resistance (MDR) bacteria represents a great problem worldwide. Survey to determine the susceptibility profile of clinical bacterial pathogenic strains to the most commonly prescribed antibiotics by physicians in Egyptian hospitals have been determined between 20/5/2013 to 15/9/2014. Out of 200 bacterial isolates, 144(72%) were Gram-negative bacilli (GNB), 54(27%) Gram-positive cocci and two (1%) were Candida spp. The most frequent pathogens were Klebsiella spp. (42%) followed Staph. aureus (16%) and E.coli (15.5%). The most resistant isolates were Pseudomonas spp. (79 %). The most efficient antibiotic was amikacin (AK) (48.5%), while most bacterial isolates were resistant to spectinomycin (SPT) (93%). The results showed that aminoglycoside antibiotics were the most efficient agents against the clinical bacterial isolates. And from the beginning to the end of the collection period, it was found that MDR bacterial isolates 186 isolates out of 200 (93%), these MDR involved 59 XDR isolates which represented 29.5%. The sensitive isolates were found to be 14 isolates (7%) from all the isolated strains. The results of MIC50 proved that amikacin (AK) having the lowest MIC against most MDR strains tested when compared with the two other antibiotics (aztreonam (ATM) and meropenem (MERO)). This results confirmed the previous results of the present study that AK was the most effective antibiotics. The percentage of growth inhibition of double, triple and four antibiotic combinations revealed that inhibition exceeded 95% for most combinations.

Keywords: Antibiotic resistance, Pathogenic bacteria, susceptibility, MDR, XDR, antibiotic combinations.


[Download Article]     [Download Certifiate]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More