Abstract

DEVELOPMENT AND EVALUATION OF ORAL MEDICATED JELLY OF ONDANSETRON HYDROCHLORIDE

Jadhav S. B.*, Bharkad V. B., Shinde M. K., Kadam V. S. and Katkam P.

ABSTRACT

The aim of present investigation was to formulate and evaluate the oral medicated jelly containing Ondansetron HCl for the treatment of nausea and vomiting. Jellies are semisolid to thick viscous fluids which is easily taken by patients of advanced age, patients with disability in ingestion of food and drink in other word those having difficulty in mastication and swallowing. The benefit of these prepared medicated jellies are increased bioavailability by passing first pass metabolism, easily taken without water and accepted by paediatrics easily. Jellies are prepared by heating and congealing method by dispersing gelling agents in water and evaluated for their physicochemical parameters like appearance, stickiness, pH, viscosity, spreadability, stability studies, drug release and content uniformity. All batches (F1-F12) of medicated jelly showed acceptable and comparable appearance, pH, viscosity, spreadability, stability studies, drug release and content uniformity. The viscosity range was found to be 619007 to 710077cps. The drug content of F1 to F12 formulations was found to be in the range of 95.21 to 103.76%. F8 batch prepared with xanthan gum shows 101.04%. drug release.

Keywords: Oral medicated jelly, Heating and Congealing, Ondansetron HCl, Gelling agents, Nausea and Vomiting.