Abstract

FORMULATION AND EVALUATION OF ETORICOXIB METHYL SALICYLATE MENTHOL MICROSPONGE GEL FOR TOPICAL DRUG DELIVERY

*Vinayak K., Ashalatha, Shabaraya A. R. and A. Sravanthi

ABSTRACT

One of the most efficient approaches of novel drug delivery system for topical application is Microsponges. These are polymeric delivery systems composed of porous microspheres. They are tiny sponge-like spherical particles with a large porous surface. Their high degree of cross-linking results in particles that are insoluble, inert and of sufficient strength to stand up to the high shear. Etoricoxib Cyclooxigenase-2(cox-2) inhibitor a non steroidal anti-inflammatory drug was formulated as microsponges using Ethyl cellulose and Eudragit RS 100 polymers by solvent evaporation method and evaluated for drug-polymer compatability by using FTIR, particle size, production yield, loading efficiency, Further selected microsponges were formulated into gel using carbopol 934(0.5% and 1%) and evaluated for various parameters like clarity, viscosity, pH, spreadability, In-vitro diffusion, Skin irritation and stability studies were performed. And it was found that all characteristic features shows significant results. The gel prepared by these microsponges shows most efficient in uniform distribution and release rate of drug than the any other form.

Keywords: Etoricoxib, microsponges, gel, topical drug delivery, controlled release.