Photo Gallery



News & Updation

  • JUNE 2018 Issue has been successfully launched on 1 June 2018

  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.



Prof. Mahesh S. Gadge*, Krishnakumar K. Saurkar and Prajakta N. Dongare


The sustained release matrix tablet of Stavudine was prepared by direct compression method using hydrophilic HPMC K4M, carbopol 934P and hydrophobic Eudragit RSPO polymers. The release of Stavudine from matrix tablet can be controlled by changing type of polymer or by its concentration. As the concentration of hydrophilic polymers increased the drug release rate from matrix tablet were decreased. By increasing concentration of Eudragit RSPO in formulation, the drug release rate also increased. In vitro release data fitted into Hixson-Crowell kinetic model suggest that the highest correlation coefficient was showed by F5 and F6 formulation batches, but present cumulative drug release for F5 was found to be 95.64% and percent cumulative drug release for F6 was found to be 92.67% as the percent cumulative drug release of F5 was higher than F6. Hence, F5 selected as an optimized batch. Optimized batch F5 were stable at the selected temperature and humidity in storage for 28 days. The best fit model was Hixson-Crowell model followed by Korsmeyer peppas, Higuchi model and first order. The value of correlation coefficient was found to be 0.998 for F5 formulation. finally it concluded that the prepared sustained release matrix tablet of Stavudine may prove to be potential candidate for safe and effective drug livery over an extended period of time.

Keywords: Stavudine, Eudragit RSPO, Sustained release, Matrix tablets, Hixson-Crowell model.

[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More