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  • WJPPS NOVEMBER ISSUE PUBLISHED
  • NOVEMBER 2017 Issue has been successfully launched on 1 November 2017

  • ICV
  • WJPPS Rank with Index Copernicus Value 52.51 due to high reputation at International Level

  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.041 to 6.647 due to high quality Publication at International Level

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    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
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Abstract

SYNTHESIS & ANTIMICROBIAL STUDIES ON NOVEL PYRIMIDINES DERIVED FROM PIPERAZINE CHALCONES

J. Ranjith Kumar*, S. Ushasri, T. Swetha, B. Sunil Reddy and MD. Yasmeen Begam

ABSTRACT

Treatment of 3-substituted phenyl-1-(4-(4- hydroxyl phenyl)- piperzin-1-yl)-Prop-2-en-1-ones with guanidine hydrochloride in presence of ethanol and potassium hydroxide, formed 4- substituted phenyl-6-(4-(4- hydroxyl phenyl)- piperzin-1-yl)- Pyrimidinyl derivatives (RP-1 to RP-10). These are assayed for their antibacterial activity against Bacillus pumilus, Bacillus subtilis, Escherichia coli and Proteus vulgaris; for antifungal activity against Aspergillus niger and Candida albicans strains. Antibacterial assay revealed that, compounds RP-2, 3, 7, 8, 10 were highly effective against Bacillus subtilis and Proteus vulgaris and in the antifungal assay, compounds RP-3, 10 proved to be effective against Aspergillus niger.

Keywords: 4- substituted phenyl-6-(4-(4- hydroxyl phenyl)- piperzin-1-yl)- Pyrimidinyl derivatives, antibacterial activity, assay, effective, antifungal activity.


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