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  • WJPPS NOVEMBER ISSUE PUBLISHED
  • NOVEMBER 2017 Issue has been successfully launched on 1 November 2017

  • ICV
  • WJPPS Rank with Index Copernicus Value 52.51 due to high reputation at International Level

  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.041 to 6.647 due to high quality Publication at International Level

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    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
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  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
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Abstract

IN-VITRO EVALUATION OF CYTOTOXIC AND APOPTOGENIC PROPERTIES OF MUCUNA PRURIENS ON MCF7 CELL LINES

Sonia Gupta, Gopinath S. M.*, Ismail Shareef M. and Ayushi Gupta

ABSTRACT

Since last two decades researchers have come up with various synthetic chemotherapeutic agents to treat breast cancer. Ironically, these synthetic agents either cause various side effects or breast cancer cells develop resistance towards them. The present study is aimed to evaluate the cytotoxic and apoptogenic properties of extract from Mucuna pruriens seeds on breast adenocarcinoma MCF7 cell lines. MCF7 cells treated with the different concentrations of ethanol extract of the plant sample was subjected to cytotoxic assay, hemolysis assay, G2M phase cell cycle studies and apoptotic studies. Mucuna pruriens seeds extract in concentration of 320μg/ml was found to induce apoptosis in 52.3% of MCF7 cells and was non-hemolytic because of which it manifest to be potential prospect to fight against breast cancer.

Keywords: Adenocarcinoma, anti-neoplastic, typtamines, Mucuna pruriens.


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