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  • WJPPS SEPTEMBER ISSUE PUBLISHED
  • SEPTEMBER 2017 Issue has been successfully launched on 1 September 2017

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  • WJPPS Rank with Index Copernicus Value 52.51 due to high reputation at International Level

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  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.041 to 6.647 due to high quality Publication at International Level

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Abstract

SYNTHESIS AND BIOLOGICAL STUDY OF SOME NEW THIAZOLIDINON DERIVATIVES

Vandana B. Patel* and M. K. Thakor

ABSTRACT

The Fused new heterocyclic compounds (3a-h) namely N-(3,5-diphenyl-3,3a-dihydrothiazolo[4,5-c]isoxazol-6(5H)-yl)-2-(5-(2-hydroxyphenyl)-2-thioxo-1,3,4-oxadiazol-3 (2H)-yl)propanamide were prepared and characterized. First Oxadiazolo - thiazolidinones (1a-h) namely 2-(5-(2-hydroxyphenyl)-2-thioxo-1,3,4–oxadiazol-3(2H)-yl)-N-(4-oxo-2-phen ylthiazolidin-3-yl) propanamide on condensation with benzaldehyde gives the benzylidine der ivatives(2a-h) namely (z)-N-(5-benzylidene-4-oxo-2-phenylthiazolidin-3-yl)-2-(5-(2-hydroxy phenyl)-2-thioxo-1,3,4 -oxadiazol-3(2H)-yl) propanamide. Such compounds (2a-h) on condensation with hydroxyl amine gives the title compounds i.e. (3a-h). All the compounds were screened for their biological activities.

Keywords: Oxadiazolo-thiazolidinones, benzylidine 1, 3, 4 - oxadiazol, antibacterial and antifungal activities.


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