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  • WJPPS SEPTEMBER ISSUE PUBLISHED
  • SEPTEMBER 2017 Issue has been successfully launched on 1 September 2017

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Abstract

A NOVEL METHOD DEVELOPMENT FOR THE ESTIMATION OF IRBESARTAN IN TABLETS BY USING REVERSE PHASE LIQUID CHROMATOGRAPHY

S. Satyasri*, M. Rama Krishna and P. Venkateswara Rao

ABSTRACT

A simple, sensitive, accurate method was developed for the estimation of Irbesartan in tablets by RP-HPLC technique. Chromatographic conditions used are stationary phase standard ODS (150 mm x 4.6 mm, 5) column, mobile phase was orthophosphate buffer: methanol in the ratio of (50:50,v/v) and flow rate was maintained at 1 ml/min, detection wave length was 258 nm, column temperature was set to 30oC and diluent was mobile phase conditions were finalized as optimized method. System suitability parameters were studied by injecting the standard six times and results were well under the acceptance criteria. Linearity study was carried out between 37.5 to 225 μg/ml levels, R2 value was found to be as 0.999. Precision was found to be 1.3 for repeatability and 0.8 for intermediate precision. LOD and LOQ are 0.205 μg/ml and 0.623 μg/ml, respectively. By using above method assay of marketed formulation was carried out 99.89% was present.

Keywords: RP-HPLC, validation, irbesartan and estimation.


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