Photo Gallery

Login

Search

News & Updation

  • WJPPS NOVEMBER ISSUE PUBLISHED
  • NOVEMBER 2017 Issue has been successfully launched on 1 November 2017

  • ICV
  • WJPPS Rank with Index Copernicus Value 52.51 due to high reputation at International Level

  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.041 to 6.647 due to high quality Publication at International Level

  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  

Abstract

SYNTHESIS, IDENTIFICATION AND ANTIBACTERIAL EVALUATION OF SOME 1,3,4- OXADIAZOLES DERIVATIVE ON 1,8-NAPHTHYRIDINE RING

Ala I. Ayoub and Mohanad Y. Saleh*

ABSTRACT

Several 1,8-naphthyridine derivative were prepared using Vilsmeier-Haack synthization. 2-chloro-3-formyl-1,8-naphthyridine was synthesized by reacting N-(pyridin-2-yl) acetamide with POCl3 in dimethylformamide. 1,8-naphthyridine group was oxidized with NIS-K2CO3 in methanol at room temperature to yield 2-chloro-3-methoxy carbonyl -1,8-naphthyridine (2), acid hydrazide was then prepared by treating the methyl ester with hydrazine hydrate in ethanol (3), the synthesis of 2-chloro-3[2(1,3,4-oxadiazol-5-thiol-1,8-naphthyridine (4) was obtained from compound(3) reaction with CS2 in basic medium, acid hydrazide was then converted to the corresponding carbothioamide (5) by treating with benzyl isothiocyanate respectively. Thiosemicarbazide (5) was reacted with mercuric oxide in methanol to produce 1,3,4-oxadiazole (6). 2-chloro-3-[2(1,3,4-oxadiazole)]-1,8-naphthyridine (8) was yielded from acid hydrazide reaction with formic acid followed by PbO2. Acid hydrazide (3) was treated with benzaldehyde to formhydrazone (9) which then reacted with PbO2 to give 1,3,4-oxadiazole (10). Finally. The structures of synthesized compounds were confirmed spectroscopically using IR and1HNMR in addition to another physical data. The newly synthesized compounds (4,6,8,10) show a significant antibacterial activity.

Keywords: heterocyclic compounds, Vilsmeier-Haack, 1,8-naphthyridine, 1,3,4-oxadiazole, 1,3,4-thiadiazole, 1,2,4-trazole.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More