Abstract

CARDIOPROTECTIVE EFFECT OF COMMELINA DIFFUSA LEAF EXTRACT ON DOXORUBICIN INDUCED CARDIOMYOPATHY IN RATS

Sule O. J.*, Arhoghro E. M. and Erigbali P.

ABSTRACT

Albino Wistar rats were pretreated with 200 and 400 mg/kg of ethanol extract of Commelina diffusa leaf for 20 days and simultaneous treatment with doxorubicin (cumulative dose of 15 mg/kg i.p. in six divided doses 2.5mg/kg body weight i.p of doxorubicin on 7th, 10th, 13th, 16th and 19th day of study). On the 20th day, parameters evaluated were, total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL), serum markers such as creatine kinase-MB (CK–MB), lactate dehydrogenase (LDH) and extent of lipid peroxidation viz. malondialdehyde (MDA) was estimated. Pretreatment with extract of Commelina diffusa at 200 and 400 mg/kg showed a significant decrease in the levels of triglycerides, cholesterol, LDL, VLDL, lipid peroxidation (MDA) and significant increase in the level of HDL when compared with the positive control p< 0.05. Extract treated groups also showed significant decrease in the levels of serum LDH and CK-MB, when compared with the positive control p< 0.05. The histopathological study of the extract treated rats further confirmed the cardio-protection of Commelina diffusa. In conclusion, ethanol extract of Commelina diffusa may confer cardio-protective function on doxorubicin induced cardiomyopathy in rats.

Keywords: Commelina diffusa, Cardio-protective, Lactate dehydrogenase, lipid peroxidation.