Photo Gallery

Login

Search

News & Updation

  • WJPPS NOVEMBER ISSUE PUBLISHED
  • NOVEMBER 2017 Issue has been successfully launched on 1 November 2017

  • ICV
  • WJPPS Rank with Index Copernicus Value 52.51 due to high reputation at International Level

  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.041 to 6.647 due to high quality Publication at International Level

  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  

Abstract

SYNERGISTIC ANTIHYPERGLYCEMIC ACTIVITY OF METHANOLIC EXTRACT OF AERIAL PARTS OF SENNA OBTUSIFOLIA AND GLIBENCLAMIDE

Sadia Israt Khanom, M. M. Maidul Islam and Mohammed Rahmatullah*

ABSTRACT

Background: Senna obtusifolia is a Fabaceae family plant found in Bangladesh and which is used in traditional medicines of the country. Antidiabetic effect has been reported for seeds of the plant. It was therefore of interest to evaluate the antihyperglycemic activity of aerial parts of this plant and synergistic effect, if any, with an antihyperglycemic drug, glibenclamide. Methods: Antihyperglycemic activity was determined through oral glucose tolerance tests (OGTT) in mice. Results: Administration of methanol extract of Senna obtusifolia aerial parts (MESO) at a dose of 400 mg per kg to glucose-loaded mice reduced blood glucose level by 22.3%. By comparison, a standard antihyperglycemic drug, glibenclamide, when administered at a dose of 10mg per kg body weight, reduced blood glucose level by 38.3%. MESO, when administered at doses of 100, 200 and 400mg per kg along with glibenclamide at 10 mg per kg, respectively reduced blood glucose levels by 39.0, 42.3, and 44.0%. Conclusion: Methanolic extract of aerial parts of Senna obtusifolia (MESO) can be a potential source of antihyperglycemic compound(s) and also can act synergistically with antihyperglycemic drugs like glibenclamide.

Keywords: Antihyperglycemic, Senna obtusifolia, glibenclamide, OGTT, mice.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More