Abstract

ONCHOCHERCIASIS (RIVER BLINDNESS): A REVOLUTION IN THERAPY

*Ronald N. E. and Okonkwo C. I.

ABSTRACT

In Abakaliki, Ebonyi State, we have recently completed clinical trials of a new drug, ivermectin (mectizan) that promises to revolutionize the treatment of river blindness or onchocerciasis. In a recent study of 100 patients, with skin biopsies, which were positive for microfilariae; we showed that ivermectin was at least as effective as the previously available standard drug diethylcarbamazine (DEC), but that ivermectin was much safer. In a larger study of 300 patients we have just completed we have confirmed both the safety and efficacy of ivermectin. These results are in agreement with other several trails following a standard protocol. There had not been the remotest possibility of realistically treating millions of people who have Onchocerciasis prior to the advent of ivermectin. This was because the previous drugs were too dangerous to use on a mass scale. Ivermectin is safe and effective. It is given in a single oral dose of as little as 6mg (for a 65kg. Weight human) that may be repeated on an annual basis. It seems to be so safe that it can be given on a mass scale within the primary health care delivery system.

Keywords: .