SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUTION OF SUBSTITUTED 2-PHENYL BENZIMIDAZOLE DERIVATIVES
Kamma.Madhavi*, N. Raghavendra Rao, N. Srinivasa rao, B.Raju.
ABSTRACT
Benzimidazole is important pharmacophore and privileged structure in
medicinal field with so many pharmacological activities. Literature
survey shows that among the Benzimidazole derivatives, 2-phenyl
Benzimidazoles are found more potent. The substituted Benzimidazole
derivatives possess different pharmacological activities antiinflammatory,
anti-microbial, antifungal, and antiulcer activities etc.
And hence the design and synthesis of 2-substituted Benzimidazoles
are potential area of research. So synthesised to N-Mannich base of
substituted 2-phenyl Benzimidazole derivatives was synthesised by
using O-Phenylene diamine with different aromatic acids with
corresponded to N-mannich base. Finally the synthesised compounds
were characterized by TLC, MP & Spectral data. Synthesised
compounds screened to antibacterial & antifungal activities by cup plate method and also
evaluated for anti-inflammatory activity determined by carrageenan induced method.
Keywords: Substituted 2-phenyl Benzimidazoles, Carrageenan induced method, antiinflammatory activity, cup plate method, antibacterial activity, antifungal activity.
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