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Abstract

FORMULATION, DEVELOPMENT AND EVALUATION OF ANTIACNE DAPSONE GEL

Ashish Gorle* and Kashiram Pawara

ABSTRACT

The present study has been undertaken with the aim to formulate and evaluate antiacne gel containing Dapsone drug. Acne vulgaris is a most common skin disorder of pilosebaceous unit that affect areas containing the largest oil glands, including the face, back, and trunk. It is generally characterized by formation of seborrhea, comedone, inflammatory lesions. Propionibacterium acnes and Staphylococcus epidermidis have been recognized as pus-forming bacteria triggering an inflammation in acne. The formulations were prepared by carbopol 971P and triethanolamine. Compatibility study between drug and physical mixture was performed by FT-IR and DSC. The formulations were characterized for various physiochemical properties such as, physical appearance, viscosity, pH, spread ability, antimicrobial activity, in-vitro drug release and stability. Compatibility study showed no any kind of interaction between ingredients used. It was observed that concentration of polymer showed effects on physical parameter and dissolution time of formulation. Gel formulations were found to have 1-2 fold enlarge in the skin deposition than conventional cream hence representing gels forms depots on skin layers and thus providing best choice to deal with acne. The results showed that the developed Gels had the ability to release the drug for the duration of about 90 minutes. Among different storage conditions the gels stored at were found to most stable, as compare to room temperature. Dapsone 5% gel was found to effective and well tolerated in non-inflammatory as well as inflammatory acne lesions.

Keywords: Dapsone Gel, anti-acne, physical characterization, in-vitro release, stability study


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