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Abstract

FORMULATION AND EVALUATION OF SUSTAINED RELEASE TABLETS OF TRAMADOL

B. Ganesh*, L. Thirupathi, T. Vijayakumari, B. Chandulal and T. Mangilal

ABSTRACT

The main aim of the proposed work was to develop Tramadol matrix tablets, sustained release dosage form. Tramadol is a narcotic analgesic proposed for moderate to severe pain Sustained release formulation is the drug delivery system that is designed to achieve a prolonged therapeutic effect by continuously releasing medication over an extended period of time after administration of a single dose. The sustained release tablets were prepared by direct compression method using Hydroxypropyl methyl cellulose as a K100M grade, Karayagum and Guar gum in varying ratios. Tablets blends were evaluated for Bulk density, Tapped density, compressibility index and angle of repose, shows satisfactory results. The compressed tablets were then evaluated for various physical tests like diameter, thickness, uniformity of weight, hardness, friability and drug content. The granules exhibited satisfactory rheological demeanor. The results of all these tests were found to be satisfactory. The in-vitro dissolution study was carried out for 12 hours using the paddle method in phosphate buffer (pH 6.8) as dissolution media. Formulation F1, to F9 direct compression method, sustain release and among all the formulation. This finding reveals that above a particular concentration of HPMCK100M, Karayagum and Guar gum and Magnesium stearate are capable of providing sustained drug release. Sustained release, HPMC-K100M, Karayagum, Guar gum, Magnesium stearate, Microcrystalline cellulose.

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