WJPPS Citation

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • New Impact Factor
  • WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

  • WJPPS: MARCH ISSUE PUBLISHED
  • March Issue has been successfully launched on 1 March 2024.

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Scope Indexed
  • WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

Abstract

MOLECULAR DOCKING STUDIES ON PHYTOCONSTITUENTS OF PLEIOSPERMIUM ALATUM AGAINST ?-AMYLASE ENZYME

J. Amutha Iswarya Devi*, R. Ramprasad and Nilsha Anil

ABSTRACT

The purpose of the study is to evaluate the α-amylase inhibitory activity of active constituents present in Pleiospermium alatum using in silico docking studies. In this perspective, active plant constituent ligands were prepared for the docking evaluation. Acarbose, a known α-amylase inhibitor was used as the standard. In silico docking studies were carried out using recentversion ofGLIDE software v5.5 developed by Schrödinger. These results showed that all the active constituents showed binding energy ranging between - 3.6 to -7.7kcal/mol when compared with that of the standard (-6.3kcal/mol). 2-Hydroxymethyl-5-(1-hydroxy-1-isopropyl)-2-Cyclohexen-1-on and 1, 2-Benzenedicarboxylic acid, diisooctyl ester contributed excellent α-amylase inhibitory activity because of its structuralpaameters. These molecular docking analyses lead to the further development to identify the potent α-amylase inhibitors for the treatment of diabetes.

Keywords: Pleiospermium Alatum, Molecular Docking, ?-Amylase, Anti-Diabetic.


[Download Article]     [Download Certifiate]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More