Photo Gallery

Login

Search

News & Updation

  • WJPPS OCTOBER ISSUE PUBLISHED
  • OCTOBER 2017 Issue has been successfully launched on 1 October 2017

  • ICV
  • WJPPS Rank with Index Copernicus Value 52.51 due to high reputation at International Level

  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.041 to 6.647 due to high quality Publication at International Level

  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  

Abstract

FORMULATION, DEVELOPMENT AND IN-VITRO EVALUATION OF RABEPRAZOLE SODIUM DELAYED RELEASE ENTERIC COATED TABLETS

C. Murali Krishna Goud*, Ravilla Dhanalakshmi and P. Ramesh

ABSTRACT

Rabeprazole sodium is a proton pump inhibitor used to treat peptic ulcer, duodenal ulcer, gastro oesophageal reflux disease by inhibiting the enzyme H+ /K+ATPase, the acidic pump. It is also used to treat Zollinger-Ellison syndrome, erosive esophagitis.This study is aimed to develop pharmaceutically equivalent and stable enteric-coated tablets of Rabeprazole sodium which protects it from acidic environment of the stomach. Six Formulations of Rabeprazole core tablets were developed using mannitol as diluents, crospovidone and polyplasdone-XL as super disintegrants, sodium carbonate anhydrous as stabilizer, magnesium stearate and talc as lubricant and glidant in different proportions, and the prepared core tablets were coated with enteric coating using hypromellose phthalate 55, myvacet, pigment blend yellow, ethanol and purified water. Compatibility studies were performed for drug, physical mixture tablet which shows no interaction. From the dissolution the formulation F6 shows highest percentage of drug release.

Keywords: Rabeprazole sodium, crospovidonepolyplasdone-XL, direct compression and enteric coated tablets.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More