N-SUBSTITUTED FLUORO BENZOTHIAZOLO SCHIFF’S BASES: SYNTHESIS AND CHARACTERISATION OF NEW NOVEL ANTIOXIDANT AGENTS
D. Ravi Sankar Reddy*, and K. Harin Kumar
ABSTRACT
Various substituted N-[6-fluoro-7-substituted benzothiazol-2-yl]-2-
(furan-2-yl methylene) hydrazine carbothioamide containing different
functional groups have been synthesized by treating fluoro chloro
aniline with KSCN in presence of bromine in glacial acetic acid and
ammonia to get 2-amino-6-fluoro-7-chloro-(1,3)- benzothiazole, which
was treated with hydrazine hydrate, carbondisulphide and sodium
chloro acetate in the presence of ethanol to get N-(7-chloro-6-fluoro
benzothiazol-2-yl) hydrazine carbothioamide, which will refluxed with
furfuraldehyde in the presence of ethanol to get newly N-(6-fluoro-7-
chloro benzothiazol-2-yl)-2-(furan-2-yl methylene) hydrazine
carbothioamide or schiff’ base. To the above schiff’s base different
substitutents in presence of Dimethyl formamide (DMF) were treated
to get newly targeted compounds through replacing at 7th position of
chlorine. The lead compounds were characterized by Melting point,
TLC, calculated elemental analysis, UV, IR, and H1 NMR spectral studies. The synthesized
compounds were tested for anti-oxidant activity by using Hydrogen peroxide scavenging
method had shown significant activity at different concentrations compared to standard; still
further studies are requested.
Keywords: Fluoro benzothiazoles, Schiff’s bases, Anti-oxidant activity.
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