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Abstract

VISIBLE SPECTROPHOTOMETRIC DETERMINATION OF BENDAMUSTINE HYDROCHLORIDE IN FORMULATION SAMPLE

T. Padmini* and Dr. L. Satyanarayana

ABSTRACT

A validate rapid, economical and sensitive visible spectrophotometric method has been developed for quantitative determination of bendamustine hydrochloride in bulk drug and formulation samples. This method is validated for irinotecan with chromogenic reagent 1:10 phenanthroline. The calibration curve is linear over a concentration range from 5-40 μg/ml. The relative standard deviation (R.S.D) is less than 2% and average recovery is above 100.00 %. The proposed method is fast, sensitive, precise, accurate and efficient and can be used for analysis in quality control laboratories.

Keywords: Ultraviolet-Visible Spectrophotometry, bendamustine hydrochloride, 1:10 phenanthroline.


[Full Text Article]

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