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  • WJPPS OCTOBER ISSUE PUBLISHED
  • OCTOBER 2017 Issue has been successfully launched on 1 October 2017

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  • WJPPS Rank with Index Copernicus Value 52.51 due to high reputation at International Level

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  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.041 to 6.647 due to high quality Publication at International Level

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Abstract

FORMULATION AND EVALUATION OF DARIFENACIN HYDROBROMIDE EXTENDED RELEASE MATRIX TABLETS

Dilip Kumar Brahma* and L. Rajesh Patro

ABSTRACT

Darifenacin is a muscarinic M3 selective receptor antagonist, which is intended for symptomatic treatment of urge incontinence and/or increased urinary frequency and urgency as may occur in patients with overactive bladder syndrome. Therefore the present investigation concerned with the development of once-a-day darifenacin hydrobromide extended release tablets to extend the duration of action up to 24 hrs by controlling the dissolution rate using different viscosity grades of HPMC. Main aim and object of my present work is to formulate darifenacin hydrobromide extended release film coated tablets and compared with the innovator product enablex, marketed by novartis. Darifenacin extended release tablets were developed to overcome the inconvenience of multiple dosing per day that is necessary with the immediate release formulation. There is therefore a need of administrating darifenacin in an oral dosage form once or twice daily in the form of extended release tablets provide therapeutically effective plasma concentrations of darifenacin for the treatment of overactive bladder in humans.

Keywords: extended release, HPMC, sympathomimetic, Darifenacin.


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