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Abstract

FORMULATION AND EVALUATION OF CETRIZINE DIHYDROCHLORIDE FAST DISSOLVING FILM FOR PEDIATRICS

Yadav Vivek, Omprakash G. Bhusnure*, Sachin B. Gholve, Kulkarni K.B., Sanjay S. Thonte and Giram Padmaja Sidram

ABSTRACT

This study aimed to develop films for potential delivery of Cetrizine Dihydrochloride via the buccal mucosa of paediatric patients. Films were prepared using hydroxy propyl methyl cellulose (HPMC E-15), hydroxy propyl methyl cellulose (HPMC K-15), hydroxy propyl methyl cellulose (HPMC K-100), hydroxyl propyl methyl cellulose (HPMC K-100), polyvinyl alcohol with propylene glycol as plasticizer, aspartame as sweetner, citric acid as saliva stimulating agent and water as solvent. The drug release for the formulations (F1 –F4) which contains 400mg of HPMC E-15, HPMC K-15, HPMC K-100, and PVA drug release was about 84.34; 96.55; 83.96; 94.28 respectively and for the formulations (F5 –F10) which contains the drug release was about 102.15; 96.55; 79.20; 88.64;95.47; 96.37 respectively. Cetrizine Dihydrochloride is freely soluble in water. Based on the in-vitro disintegration time, formulation F2 and F5 were found to be promising and showed a disintegration time of 20 and 18 sec respectively. However this FDF is useful for the improving of the bioavailability of the drug.

Keywords: Cetrizine Dihydrochloride, FDF, Solvent Casting Method, In-vitro Study.


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